Author: Ben Carter, Jack Williams2, Richard Evans3
Research
Biomarkers of Neuronal Injury and Amyloid Metabolism in the Cerebrospinal Fluid of Patients Infected with HIV-1 Subtypes B and C
Ben Carter1, Jack Williams2, Richard Evans3, Chloe Davies4, Karina Nguyen4
1Department of Infectious Diseases, Imperial College London, London, UK
2Department of Viral Immunology, University of Cambridge, Cambridge, UK
3Department of Microbiology, Monash University, Melbourne, Australia
4Department of Medical Microbiology and Immunology, University of British Columbia, Vancouver, Canada
Available Online: 09-Mar-2014
Abstract
HIV-1 infection is associated with neurological complications, but the pathogenesis may vary across HIV-1 subtypes. This study investigates biomarkers of neuronal injury and amyloid metabolism in the cerebrospinal fluid (CSF) of patients infected with HIV-1 subtypes B and C. We hypothesize that subtype-specific differences exist in these biomarkers, potentially contributing to variations in neurological outcomes. CSF samples were analyzed for neuronal injury markers (neurofilament light chain, NFL) and amyloid-beta peptides (Aβ40, Aβ42). Results suggest potential subtype-related differences in biomarker profiles, warranting further investigation into the neuropathogenesis of HIV-1 subtypes.
