Author: Adrien Millet
Short Communication
Association Between Pro12Ala Polymorphism and Type 2 Diabetes Risk in Populations
Adrien Millet*
Department of Immunology, University of Franche-Comté, Besançon, France
Published: 20 December 2016
Abstract
Type 2 diabetes (T2D) is a chronic; multifactorial metabolic disorder characterized by insulin resistance and pancreatic β-cell dysfunction. It is one of the most prevalent diseases worldwide; leading to significant morbidity and mortality. The disease is driven by both genetic and environmental factors that work in tandem to disrupt glucose homeostasis. Among the numerous genetic factors implicated in the pathogenesis of T2D; the Pro12Ala polymorphism (rs1801282) in the PPARG gene has gained considerable attention
